Ichthyosis Essay Example for Free

Ichthyosis Essay While the ichthyoses constitute a rather large spectrum of about 20 cornification disorders that fit the definition and about 10 with more localized symptoms, they all are various permutations of a hyperkeratotic skin disorder that are characterized by an overgrowth and thickening of the corneal layer of the epidermis with localized erythema, and are classified from their; genetic or acquired origin, inheritance patterns, gene defects, etiologically as enzyme deficiencies, structural protein defects, regulatory protein defects, or other, and clinically as a syndromic ichthyosis, non-syndromic ichthyosis, or as a related condition. The term â€Å"ichthyosis† is derived from the Greek word ‘ichthys’ meaning ‘fish’. And aptly named as it is, a patient with ichthyosis will present with scaly dry ‘fish-like’ skin. The severity of scaling in ichthyotic patients runs a very broad spectrum, from severe to mild, where it blends into the realm of ‘dry skin’, or xerosis. The most minor of the ichthyoses, ichthyosis vulgaris, in its’ more mild forms, presents with light flaking and irritated apperence can be confused with simple xerosis. While the skin of patients with lamellar ichthyosis, is characterized by heavily pigmented, plate (armor) like armor scales that are both obvious and often debilitating. And while all forms of ichthyosis present with a flaky or scaly appearance, several other characteristic clinical features are used as hallmarks of a particular types of ichthyosis so as to distinguish them from one another. In general congenital forms such as lamellar ichthyosis, congenital ichthyosiform erythroderma, epidermolytic hyperkeratosis, and ichthosis bullosa will present at birth with a yellow, tight and shiny, ‘collodion-like’ membrane which sheds in 2-3 weeks to reveal a flaky dry skin and in cases of ichthyosis bullosa, redness and blistering, especially over flexures. The traits of congenital ichthyosis, from obvious scaly appearance, to inflexibility and pain, are all permanent and life-long conditions that even after stabilization and survival are strongly inhibitory to normal psychological and sociological development. With such a dramatic difference in appearance and physical performance, ichthyosis sufferers are very nearly always ostracized as children, often with negative effects and stunted development. The two basic types of ichthyosis are defined by their method of origin as either genetic or acquired. In inherited ichthyosis; specified as autosomal dominant, autosomal recessive, and X-linked, a mutation in a gene causes an abnormality in the normal life cycle of skin, leading to a build-up of excess skin either because of the overproduction of the replacement skin cells or because when the time comes when old cells have to be drop off they do not separate very well from the surfaces of the skin. This disruption will result to accumulation of skin cells to thick flakes which may look like fish scales, adhering themselves to the body. Acquired ichthyosis often appears as a manifestation of systemic disease, described in association with malignancies, drugs, endocrine and metabolic disease, HIV, infection, and autoimmune conditions It is usually is associated with people who have Hodgkins disease but it is also occurs in people with mycosis fungoides, other malignant sarcomas, Kaposis sarcoma and visceral carcinomas. It can occur in people suffering from leprosy, AIDS, tuberculosis, and typhoid fever. With such a rate of variation between the severity of various ichthyotic conditions and the degrees of variance within the conditions themselves, it is impossible to place a single prognosis or plan of treatment on ichthyosis or any ichthyotic condition in particular. In actuality since ichthyosis is such a rare disorder with such a low rate of incidence; with the most common, ichthyosis vulgaris at 1 in 250, X-linked at 1 in 6,000 in males and ichthyoses in their entirety at about 1 in 250,000, more often the not, it must be evaluated and treated on a case to case basis. However despite the tremendous margin of difference between conditions the basic objective remains the same, to aid the skin in retaining moisture, shedding, and in the promotion of a softer, suppler, more flexible skin surface. While no cure for ichthyosis exists the current treatment options for an ichthyotic patient are topical therapy, bathing, and mechanical scale removal, along with psychosocial support for patient and family via patient organizations. Topical therapy focuses on the regeneration of the epidermal barrier by water binding, Transepidermal Water Loss (TEWL) reduction and reformation of the lipid barrier or anti-inflammation with the regular use of ointments containing lipids, keratolytic, and/or hydrating substances. Therapeutic bathing seeks to loosen scales and residual medications in addition to hydrating the skin with bland baths up to twice a day with sodium bicarbonate, wheat, corn, or rice starch, during which scales and hyperkeratoses are mechanically removed using repetitive gentle rubbing using microfiber household towels, pumice stones, or special silk gloves. Typically the prognosis for very poor for infants born with the most severe ichthyoses, such as epidermolytic hyperkeratosis and harlequin ichthyosis where the child is born with severe blistering and huge, thick scales punctuated by deep fissures, if the infant doesn’t die within the first few days of life from dehydration, the next several weeks leave the neonate extremely prone to infection, sepsis and death. While if an infant does survive into its’ first few months of life, the chances of survival are relatively good, as with the other degrees of ichthyosis, once the conditions’ more life-threatening symptoms have been stabilized, the survivability rate is much better and work can begin to be done on improving the quality of life. In cases such as these tremendous advancements have been made with the introduction of specialized intensive care units and a recent evolution of Retinoid medications, along with the various creams, salves and ointments aimed at moisturizing the skin and aiding the skin in shedding. Of the topical lotions, ointments and creams themselves, advancements have been made in the use of nanotechnology, in order to more finely mill the medications in the salves into nano-sized particles, greatly increasing the absorption into the skin and productiveness of topical treatment. Since ichthyosis is a genetic disorder the search for an absolute â€Å"cure† has been largely limited to gene therapy and stem cell research, the latter of which is hindered by legal and ethical debate, while the former has been extremely restricted since a string of gene therapy related deaths in 2002, since which gene therapy has been largely limited to severe autoimmune diseases with fatal prognosises. So the bulk of ichthyosis-related research has been directed toward creating new products to alleviate the symptoms and provide a higher standard of living. However in 2009, a major victory was won for the sufferers and researcher of inherited ichthyosis, when the conclusion of the First Ichthyosis Consensus Conference held in Soreze, France, on January 23 and 24, 2009, where subcommittees on different issues proposed terminology that was debated until consensus was reached. The classification project started two years prior, at the First World Conference on Ichthyosis in 2007. And after its’ completion, allowed for a universal system of taxonomy was adopted for the nomenclature involving inherited ichthyosis. Works Cited http://emedicine.medscape.com/article/1198130-overview

Two big hearted river :: essays research papers

Of the stories on the syllabus the one that I most closely related to was â€Å"The Big Two-Hearted River† by Earnest Hemmingway. During my first reading of this story it was the setting and the action of the main character Nick Adams that I connected with. Reading the opening sentences, grand visions of my childhood danced through my head. The story took me back to happy times of summers spent alone with my grandfather in the mountains of West Virginia. Like Nick, the camping and fishing trips were a welcomed relief from the city life and school for me. Although we were in a different area of the country the wilderness seems to be the same. Like Nick I remembered being dropped off near the edge of the wilderness to hike in and go camping near the river. â€Å"The river just showed through the trees† (Hemingway 480). As with the main character the river always intrigued me as a child. It was many things such as the smell, the sound, and the being apart of nature that I liked. Most of all I really loved having the one on one time spent with my grandfather. Just as Hemmingway describes, we to would tromp through the mountains for what seemed like forever. We make the trek all in order to find that perfect spot to set up camp. I oft en felt as Nick did â€Å"His muscles ached and the day was hot but†¦felt happy† (Hemingway 468). When we came across that spot, a quote from the story says it best â€Å"He was there, in the good place† (Hemingway 471), and â€Å"The river was there† (Hemingway 467). A sense of happiness filled my body because I knew what was soon to come. We would set up the camp and get something to eat. I could feel Nick’s pain of being â€Å"very hungry† (Hemingway 470); this was one of the down sides of the trip. My grandfather would not stop just to eat we would have to find are site then we would take a break for a quick snack before setting up camp. First we would survey the site and plan the best placement for our things. Hemingway wrote â€Å"He pegged the sides out taut and drove the pegs deep† (470), this passage brought flash backs of my grandfather telling me how important it was to get the lines tight and drive the tent pegs deep into th e ground.

Outline two perspectives on learning Essay

Classical Conditioning is when behaviour is learned through a stimulus response bond (S_R) This is done by using unconditioned stimuli as well as conditioned stimuli. Simply put this method of behaviourist learning is able to create behaviour that doesn’t normally exist (e.g. salivating at the sound of a bell) this is done through association. For example if a person was to ring a bell right before they fed the dog, the dog would salivate due to the presence of the food. If done enough times, the dog would salivate at the sound of the bell alone, even if no food was present (Pavlov’s experiment) Operant Conditioning is used to shape behaviour that already exists in the learner. This is done through reinforcement whether it be positive (rewarding) negative (taking away a negative trait) or punishment Skinner found that people are more likely to learn a behaviour if they are rewarded after doing it (e.g. praise, gifts etc.)  SLT refers to Bandura’s research, as he believed that people can learn through vicarious learning watching other people doing or not doing as they do. This is done by Modelling, which can mean to make an example of a peer in school, thus showing others how to, or not to act. Humanistic Carl Rogers believed that people learn best when they are given/shown Unconditional positive regard, empathy and genuiness. This looks at learners as human beings with sensitivities and self esteem as opposed to machines which can be programmed (behaviourist) Maslow was another humanistic believers he created the hierarchy of needs, suggesting that the learners needed their basic needs to be satisfied (food safety belingingess) before they can learn and have the desire to explore the â€Å"meta needs† (learning etc.)    Due to the fact that the three perspectives are so different in design, it can be very difficult to say how one method is nomothetically better than another. Each perspective has its own strong and weak points.  The behaviourist perspective is a very affective method of learning as performance levels tend to be at the highest when the techniques of classical, Operant and SLT are applied. However this suggests that people learn only what they show, valuing nothing but the behaviour of the learner. For example the use of Classical Conditioning can create associations which can benefit the learner (e.g. standing up when a governor enters the room) as it can avoid embarrassment however, it can also be considered unethical to use such techniques as learners ten can become unable to control their own actions as the SR bond created put their behaviour in the control of the subconscious therefore using classical conditioning techniques would not be best when trying to teach something of a creative nature (e.g. art, music etc.) as personal control is very important in these subjects Another ethical issue with the use of behaviourist tactics in learning is that the reinforcement can hurt the learner’s self esteem. This can be seen in Operant Conditioning techniques like punishment in that although the behaviour may be shaped to an â€Å"acceptable standard†, the learners would become less motivated to produce work. This can also play a role in bad association between the student and the subject being taught in that they don’t like how the behaviourists teacher treats them, they would learn to dislike the subject as opposed to simply the teacher. The Humanistic view, due to the fact that they value the development of the person more than the acquisition of trivial knowledge, can often very poor exam results within schools. An example of this would be the Summerhill school (Neil) which applied a completely humanistic approach to the workings of the school (e.g. no reinforcement of class attendance, no rules etc.) the results of this experiment showed that with the humanistic perspective, exam results were poor, however follow up studies showed that psychological problems and better stability within alumni Another possible criticism of the humanistic views of Maslow is that there are people who can learn in school very well yet not have all of their basic needs satisfied (e.g. negligent parenting) however it can be said that the higher meta needs would be easier to pursue if the basic needs were provided for the learner. This goes against Maslow’s theory in that the hierarchy of needs can have exceptions based on individual differences (which can be analysed in the Myers Briggs Personality Indicator) Cognitive psychologists believe that all information can be presented in a way that’s best taken on by the learner. However this goes against the theories of Piaget and Ausubel who thought that information was exclusively better if present in certain ways, (bit by bit versus all encompassing respectively) The cognitive approach doesn’t consider the learners as anything but information processors, which can also hurt students self esteem as they are not necessarily regarded as human beings who are valued (Rogers) When it comes down to it each perspective is very helpful to the improvement of learning within children however if used exclusively can cause their own contrasting problems. The best way in my eyes is to create a hybrid of the systems, for example, in regards to dealing with disruptive behaviour a behaviourist system of punishment be most effective, but then followed up with a humanistic debrief, (explaining why being punished) this would allow the student to learn the behaviour as well as maintain or reinforce self esteem.

test bank Essay - 1790 Words

Chapter 2—Social Responsibility MULTIPLE CHOICE 1. Stakeholders power over businesses stems from their a. ability to withdraw or withhold resources. b. ability to generate profits. c. media impact. d. political influence. e. stock ownership. ANS: A PTS: 1 2. Those who have a claim in some aspect of a firms products, operations, markets, industry, and outcomes are known as a. shareholders. b. stockholders. c. stakeholders. d. claimholders. e. special-interest groups. ANS: C PTS: 1 3. Which of the following do not typically engage in transactions with a company and thus are not essential for its survival? a. Employees b. Secondary stakeholders c. Primary stakeholders d. Investors e.†¦show more content†¦ANS: A PTS: 1 15. Public health and safety and support of local organizations are issues most relevant to which stakeholder group? a. Investors b. Community c. Suppliers d. Customers e. Employees ANS: B PTS: 1 16. Minimizing the use of energy and reducing emissions and waste are issues of importance to which stakeholder? a. Environmental groups b. Suppliers c. Employees d. Industry leaders e. Investors ANS: A PTS: 1 17. The idea that the mission of business is to produce goods and services at a profit, thus maximizing its contribution to society is associated with a. Adam Smith. b. Theodore Levitt. c. Norman Bowie. d. Herman Miller e. Milton Friedman. ANS: E PTS: 1 18. The originator of the idea of the invisible hand, which is a fundamental concept in free market capitalism, was a. Adam Smith. b. Theodore Levitt. c. Norman Bowie. d. Herman Miller e. Milton Friedman. ANS: A PTS: 1 19. Some economists believe that if companies address economic and legal issues, they are satisfying the demands of society, and that trying to anticipate and meet additional needs would be almost impossible. Which economist’s theory are they following most closely with this belief? a. Adam Smith. b. 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